The top enriched pathways (B-H p < 0.05) show many biological processes relevant in tumorigenesis and cancer progression such as DNA repair mechanisms, cell cycle regulation, epithelial–mesenchymal transitions, DNA methylation, transcriptional repression signaling and senescence pathway as well as, several pathways related to estrogen receptor activity, such as estrogen receptor signaling and estrogen-mediated S-phase entry. The gene discussed is ESR1; the disease is cancer.