Recent meta-analyses of genetic factors suggested that β3-adrenergic receptor gene Trp64Arg (T64A) polymorphism may be associated with an increased risk for essential hypertension by reducing cellular-signal transduction from repair that prevents adipose-tissue heat production and decomposition [29], and alpha epithelial sodium channel gene (alpha-ENaC) T663A polymorphism may also be associated with essential hypertension through pathogenesis concerning sodium reabsorption [30]. Here, SCNN1A is linked to essential hypertension.