In addition, we observed that IL-22 deficiency resulted in increased gene expression of diverse innate immune molecules in the lungs after infection, including Itgb2, Tlr2, Clec7a, Cysltr1, Cd36 and Ltb4r1 after 7 days, and Tlr2, Cd36, Ltb4r1, Alox5ap, Cd14, Tlr4, Ticam2, Mrc1, Myd88, Tlr6, Alox5, Ptgs2, Ptgse2, Tlr1 and Ticam1 after 14 days of infection (Figure S1). The gene discussed is TLR2; the disease is infection.