miR-15a-16, miR-15b, and Cripto expression have been shown to be inversely correlated in non-small lung cancer (NSCLC) [79] and glioma cells [80], whereas let-7 microRNA family members, such as LIN28B and TGFBR1, indirectly modulate Cripto expression by targeting known regulators of stem cell pluripotency maintenance [81]. The gene discussed is LIN28B; the disease is central nervous system cancer.