The reactivation of Cripto has been associated with tumorigenesis and although genomic aberrations in the Cripto gene itself have not specifically been reported in human cancers, aberrantly high levels of Cripto expression or experimental overexpression have oncogenic effects, such as the promotion of EMT, angiogenesis, and increased cell proliferation and migration in in vitro and in vivo experimental models [1]. The gene discussed is CRIPTO; the disease is cancer.