This characterization was performed for two transcription factors (ATF5 and SMAD3) and one stem cell marker (PRMT1) found in TCF7L2 distal program and activated during CML blast crisis (Figure 2D–I) and harboring important TCF7L2 CHIP-seq signal (Supplementary Table S2). Here, SMAD3 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.