Especially the TCF7L2 epigenetic program was found to merge with distal intervals compatible with active enhancers genomic segments near some transcription factors, such as ATF5, which has already been shown to be implicated in the regulation of autophagy of CML cells via the regulation of mTOR downstream BCR-ABL [17]. This evidence concerns the gene ATF5 and chronic myelogenous leukemia, BCR-ABL1 positive.