Interestingly, in nasopharyngeal carcinoma (NPC), astrocytoma, and epithelial ovarian cancer tissues, immunohistochemistry (IHC) was used to show expression of MNK1 or phospho-MNK1 in the nuclei, whereas phospho-eIF4E was more readily observed in the cytoplasm [55,57,61]. Here, MKNK1 is linked to astrocytoma (excluding glioblastoma).