Hyperglycaemia, alone can trigger inflammation by activating the pro-inflammatory transcription factor nuclear κB (NF-κB), resulting in an increased inflammatory chemokine and cytokine release including interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-α (TNF-α), among others. This evidence concerns the gene TNF and Hyperglycemia.