Depletion of RECQ1 sensitizes cancer cells to a variety of chemotherapeutics, namely, camptothecin [19], psoralen, hydroxyurea [20], temozolomide [29], melphalan [54] and gemcitabine [34], suggesting that RECQ1′s functions in DNA repair are important in cellular resistance to these therapeutic agents in cancer cells. This evidence concerns the gene RECQL and cancer.