TGFB1 and neoplasm: Suitably, the TGF-β pathway was represented in the respective GO-derived hub gene signature by upregulated TGFB2 gene, while other TGF-β signaling-associated genes were identified as DEGs as well, including overexpressed TGFB1. Both TGFB1 and TGFB2 are recognized as being heavily linked to EMT and tumor progression [38,53].