Furthermore, the present results for IGF1R and MDM2 inhibitors corroborated those of a recent study on numerous cancer liver cell lines providing experimental evidence of an augmented efficacy of IGF1R inhibitor linsitinib as well as of MDM2 inhibitor nutlin-3 against liver cancer lines with prominent hepatoblast/hepatocyte-like characteristics [36], thus supporting the validity of our approach. Here, MDM2 is linked to cancer.