More recently, several synthetic ligands such as LY700307, WAY200070, and 8β-VE2 have shown a high selectivity for ERβ in different experimental models and promising effects on proliferation, inhibition, and invasiveness suppression in BC, including TNBC [82,83,84,85,86], and are currently being investigated for their therapeutic use. This evidence concerns the gene ESR2 and breast cancer.