ESR2 and breast cancer: Different studies reported the use of DPN as ERβ agonist in TNBC, however, the final effects of its application are discordant; Austin et al. reported that DPN is able to activate ERβ and increase TNBC cell migration [33]; on the contrary, Song and colleagues demonstrated that ERβ activation by DPN has an inhibitory effect on migration in different BC cell lines [81].