Migraine has strong genetic roots with some genetic polymorphism specifically related to type 1 familial hemiplegic migraine (FHM1) (CACNA1A gene encoding P/Q type calcium channel) and type 2 familial hemiplegic migraine (FHM2) (ATP1A2 gene encoding Na/K ATPase), associated with differential phenotypes in response to minor head trauma [59]. Here, CACNA1A is linked to familial or sporadic hemiplegic migraine.