CRP and concussion: Based on one cross-sectional cohort and another retrospective study without healthy controls as a comparing group [26,27], increased chronic reactive protein (CRP) concentrations at baseline in mTBI patients may independently predict the onset of persistent post-concussion symptoms (PPCSs), psychological impairments, cognitive dysfunctions, white matter tract alterations related to abnormalities in functional connectivity linked to abnormal pain modulation, and contribute to the onset/maintenance of chronic persistent headache (CPH).