MLKL and non-small cell lung carcinoma: Although pyroptosis was not found to be involved in the effect of gefitinib in ID1 overexpressing NSCLC cell lines [28], it has been proven that MLKL signaling activates the NOD-like receptor protein 3 (NLRP3) inflammasome, triggering caspase-1 processing of the pro-inflammatory cytokine, IL-1β.