Intriguingly, IFNγ released from CD8+ T cells downregulates the expression of SLC7A11 and of SLC3A2, another subunit of the glutamate-cystine antiporter system (xCT), henceforth, limiting the uptake of cystine by tumor cells, promoting tumor cell lipid peroxidation and ferroptosis [102] (Figure 2). The gene discussed is SLC7A11; the disease is neoplasm.