K-Ras pancreatic cancers with active TGF-β pathways (50%) upregulate the Snail family transcriptional repressor 1 (SNAIL), thus repressing KLF5 expression and, in parallel, activating AKT switch ID1 regulation by TGF-β from repression into induction. The gene discussed is KRAS; the disease is familial pancreatic carcinoma.