Similarities in clinical manifestations and overlaps in histopathologic and CD34 immunostaining profiles with other tumors require DFSP to be differentiated from other benign and malignant lesions including dermatofibroma, schwannoma, cutaneous neurofibroma, solitary fibrous tumor, intradermal spindle cell lipoma and spindle cell or desmoplastic melanoma. The gene discussed is CD34; the disease is solitary fibrous tumor.