KDR and neoplasm: To actively target tumor cells over-expressing VEGFR, the PLGA-NPs were loaded with a recombinant human VEGF-A165 (rhVEGF) analog by the 1-Ethyl-3-[3-dimethylaminopropyl] carbodiimide hydrochloride/N-hydroxysuccinimide (EDC/NHS) covalent coupling method.