MYC and neoplasm: A direct correlation between ribosome biogenesis and the ability of Myc to promote tumorigenesis was shown first by Barna and co-workers, who demonstrated that loss of one single allele of RpL24 or RpL38 in Eμ-Myc mice decreased the incidence of lymphoma by 20% and delayed tumor onset, along with the re-establishment of accurate translational control and genome stability.