Therefore, this study aims to compare the immunohistochemical expression of EGFR versus αvβ6, integrin β3, carcinoembryonic antigen (CEA), epithelial cell adhesion molecule (EpCAM), urokinase plasminogen activator receptor (uPAR), and vascular endothelial growth factor A (VEGF-A) as targets for FGS of high-risk CSCC and HNSCC. The gene discussed is PLAUR; the disease is head and neck squamous cell carcinoma.