In order to study the ability of NDV to replicate in GBM CSCs, we infected the cells at a low MOI (0.01) and monitored the viral growth kinetics as well as the induction of the transcription of IFN-β and MX1, a gene highly expressed exclusively under IFN detection, over a time course of 120 h. The gene discussed is IFNB1; the disease is glioblastoma.