,69 Although both CD4+ T cell-mediated and CD8+ T cell-mediated immune responses have been reported to protect against ocular HSV-1 infection in naive mice,37,70 adoptive transfer and in vivo T cell subset depletion studies suggest that CD8+ T cells alone are sufficient,71–74 CD4+ T cells alone are sufficient,75–78 or that CD8+ and CD4+ T cells act together37,75,79 to induce eye disease. Here, CD4 is linked to eye disorder.