Although somewhat anecdotal, it is of interest that one (of five) woman with an NLRP5 mutation, ascertained following the birth of a child with a multi-locus imprinting disorder, also had a child with an isolated (i.e., apparently non-syndromic) CHD (atrial septal and ventricular defects) [43]. This evidence concerns the gene NLRP5 and coronary artery disorder.