In our previous studies, we had also detected some other valuable diagnostic biomarkers for NMO, such as neurofilament,27 soluble syndecan‐1 (sCD138),28 soluble cluster of differentiation 27 (sCD27),29 Chitinase‐3‐like‐1 (alias YKL‐40, yet not published), pyrin domain containing 3 (NLRP3) inflammasomes.30 The gene discussed is CHI3L1; the disease is neuromyelitis optica.