In our previous studies, we had also detected some other valuable diagnostic biomarkers for NMO, such as neurofilament,27 soluble syndecan‐1 (sCD138),28 soluble cluster of differentiation 27 (sCD27),29 Chitinase‐3‐like‐1 (alias YKL‐40, yet not published), pyrin domain containing 3 (NLRP3) inflammasomes.30 This evidence concerns the gene NLRP3 and neuromyelitis optica.