Examination of their tumor expression patterns revealed that ZNF446 is upregulated in breast tumors, an increase that trends with reduced survival in the triple-negative enriched basal-like subtype of breast cancer (HR = 1.89; p=0.059) (Figure 4—figure supplement 1A and B; Perou et al., 2000; Sørlie et al., 2001). This evidence concerns the gene ZNF446 and breast cancer.