Conversely, in luminal tumors, which are traditionally ER+ and exhibit tumor-suppressive TGFβ signaling, RRAD expression correlated with improved overall survival (HR = 0.63; p=0.01) and no correlation was observed with distant metastasis free survival (HR = 1.12; p=0.55) (Figure 2—figure supplement 1C; Perou et al., 2000; Sato et al., 2014). The gene discussed is TGFB1; the disease is neoplasm.