AF cells residing in the disc AF tissue areresponsible for synthesizing and secreting specific ECM macromolecules (i.e.aggrecan and collagen I), which ultimately supports disc AF biomechanical functionsthrough regular structural arrangement [28].In the present study, we mainly aimed to investigate the effects and mechanism ofhigh glucose on disc AF cell apoptosis. The gene discussed is ACAN; the disease is atrial fibrillation.