Moreover, CYP3A4 (OMIM#: 107910), HSD17B14 (OMIM#: 124010), HSD3B7 (OMIM#: 607764), HSD17B7 (OMIM#: 606756), and CYP11A1 (OMIM#: 118485) were exclusively significantly expressed in severe hypospadias (p < .05) (boxplots for Z‐score mRNA expression are shown in Figure 2b). This evidence concerns the gene CYP11A1 and hypospadias.