Some major differences are the overall frequency of cases (more frequent in Caucasian than Japanese populations),2 proportions of tumor subtypes (higher frequency of acral lentiginous melanoma [ALM] and mucosal melanoma compared with Caucasians), types of mutations (lower proportions of BRAF mutations compared with Caucasians) and tumor site (sole of the foot in Japanese patients compared with the trunk in Caucasian patients).4, 5, 6. Here, BRAF is linked to acral lentiginous melanoma.