GPT and hypothyroidism: In the present study, the most common ADRI with more than 2%, which also tended to be serious ADR, were liver disorder, hepatic function abnormal, and aspartate aminotransferase and alanine aminotransferase increased; rash, pruritus and skin disorder; diarrhea, colitis and enterocolitis; and hypothyroidism, hypopituitarism, adrenal insufficiency and hypophysitis.