Since, there is little evidence for a role of GAD65 similar to that of GAD67 in human schizophrenia and null mutation of the GAD65 gene in mice develop a phenotype of increased anxiety and pathological fear memory reminiscent of posttraumatic stress disorder (Müller et al. 2015), we focused on GAD67 deficiency in mice. This evidence concerns the gene GAD1 and post-traumatic stress disorder.