The role of ADRB3 in tumor immunity was investigated using mouse tumor models with invasive mouse lung carcinoma (LLC, 2 × 106 cells per mouse) established in C57BL/6 background ADRB3−/− (A 306 bp genomic fragment containing the sequences encoding the third through the fifth transmembrane domains was replaced with a neomycin selection cassette) and their ADRB3+/+ littermate. Here, ADRB3 is linked to neoplasm.