Because Lee et al. showed a significant relationship between the level of TSH and FGF21, FGF21 might be related to the progression of liver fibrosis involving TSH.21 Thyroid hormones could control the development of fibrosis through an effect on adiponectin regulation.22, 23 Kowalska et al. demonstrated that, after L‐thyroxine treatment, insulin sensitivity significantly improved in patients with subclinical hypothyroidism.17 Therefore, L‐thyroxine treatment in patients with subclinical hypothyroidism might have a beneficial effect on NAFLD and liver fibrosis. This evidence concerns the gene ADIPOQ and Hepatic fibrosis.