A significant increase in Tregs was observed in CD after anti‐TNF‐α therapy.18 FoxP3+ cells in blood were increased after anti‐TNF‐α treatment.17 FoxP3+ Treg frequency was lower in patients with active IBD, a significant increase in the circulating frequency of Tregs after anti‐TNF‐α infusion therapy, which paralleled a reduction of IBD.17 This evidence concerns the gene TNF and inflammatory bowel disease.