CD4 and inflammatory bowel disease: The gut microbiome would be important for the development of IL‐10 and induced FoxP3+ Tregs peripherally.26, 27, 28 Clostridium bacteria might be potent inducers of FoxP3+ Tregs in the colonic mucosa.29 CD4+CD8+ αα (DP8α) colonic Tregs produced IL‐10 under the influence of Faecalibacterium prausnitzii, and DP8α lymphocytes in the LP and peripheral blood were lower in IBD, suggesting that DP8α Tregs may control or prevent inflammation of IBD.30