A reduced ratio of Tregs in the peripheral blood of IBD has been reported, whereas FoxP3 mRNA levels in the mucosa are elevated in IBD.11 Tregs are also increased in the lamina propria (LP) and decreased in blood in CD patients.12, 13, 14, 15 Tregs have also been significantly increased after infliximab (IFX) treatment.16, 17, 18. The gene discussed is FOXP3; the disease is inflammatory bowel disease.