A higher prevalence of hs-CRP ≥3 mg/l was associated with CRP rs1205 CC (PR 1.64; 95%CI 1.15–2.33; p = 0.006), metabolic syndrome (PR 1.50; 95%CI 1.05–2.15; p = 0.025), age (PR 1.03; 95%CI 1.01–1.06; p = 0.024), IL6 level (PR 1.03; 95%CI 1.01–1.05; p = 0.003), SBP (PR 1.01; 95%CI 1.002–1.02; p = 0.013), HDL-c (PR 0.98; 95%CI 0.97–0.99; p = 0.024) and waist circumference ≥ 88 cm (PR 2.46; 95%CI 1.67–3.64; p < 0.001). This evidence concerns the gene CRP and metabolic syndrome.