Furthermore, lncRNA FMR4 originating from Fragile X mental retardation 1 (FMR1) locus, which aberrant expansion causes autism [76], was able to improve hNPCs development, furthermore, dysregulation of FMR4 contributed to the pathophysiology Fragile X syndrome and/or Fragile X tremor/ataxia syndrome [77]. Here, FMR1 is linked to cerebellar ataxia.