In the age group < 50 years, the mean (95% CI) number of AD visits with autoimmune diagnoses PPPY in pdC1-INH groups was 2.0 (0.381, 3.583) in females versus 0 in males, and 4.7 (1.178, 8.243) in females versus 0.6 [− 0.213, 1.505] in males for “Other (non-C1-INH) treatments” (Table 2). Here, SERPING1 is linked to Alzheimer disease.