We have recently demonstrated that transmembrane protein 16A (TMEM16A), an important component of calcium-activated chloride channels and in the maintenance of homeostasis of the airway surface fluid in airway epithelium, is also increased together with MUC5AC in CRSwNP, possibly as a direct effect of Th2 cytokines present in sinonasal mucosa [6]. The gene discussed is MUC5AC; the disease is chronic rhinosinusitis with nasal polyps.