Using primary HNECs derived from patients with CRSwNP and control subjects, this study has for the first time demonstrated that EGF significantly increases the expression of TMEM16A and MUC5AC at both gene and protein levels, as well as the percentage of TMEM16A-positive cells, MUC5AC-positive cells and cells coexpressing TMEM16A and MUC5AC. The gene discussed is EGF; the disease is chronic rhinosinusitis with nasal polyps.