To clarify the role of asiaticoside in inhibiting TGF-β1-induced MMT and ROS generation, we focused on the pro-fibrotic signaling pathway TGF-β/Smad and the antioxidant signaling pathway Nrf2/HO-1 to illustrate a potential method for inhibiting PF. This evidence concerns the gene NFE2L2 and pemphigus foliaceus.