SPP1 and Alzheimer disease: Glia/inflammation panel members SMOC1, ITGAM, and MAPT also replicated in AD CSF [6], and with the exception of GSN and KRT2, all overlapping members of the myelin panel (NEFL, NEFM, SPP1, and SOD1) and metabolism panel (PKM, FABP3, and ALDOA) were also consistent between discovery and replication cohorts (Fig. 3b).