Overlap with the neuronal/synaptic panel included the protein products of 11 genes (MAP2, GDA, NPTXR, GAP43, VGF, SYN1, BASP1, PACSIN1, YWHAB, YWHAZ, and UCHL1) and with the exception of NPTXR and VGF, which decreased in the discovery CSF dataset, all other neuronal panel members were significantly and specifically increased in the AD replication cohort. This evidence concerns the gene SYN1 and Alzheimer disease.