HSD17B6 and cancer: In addition, treatment with 5-aza-2′-deoxycytidine, a DNA-hypomethylating agent, upregulated the mRNA expression of HSD17B6 in live cancer cell lines (HepG2, Hep3B and HuH-7) based on the data from GSE5230 and GSE35313 datasets (p < 0.05, Fig. 7b, c).