As shown in plots using the Kaplan–Meier Plotter platform, an intriguing TCGA analysis tool, down-regulation of HSD17B6 expression was closely correlated with shorter OS (p = 3.9e−5), PFS (p = 0.00024), RFS (p = 0.00022) and DSS (p = 0.00023) (Fig. 3a–d), indicating a poorer prognosis with lower HSD17B6 level in HCC. Here, HSD17B6 is linked to hepatocellular carcinoma.