Previous study has identified it as a prognostic biomarker of perihilar and distal cholangiocarcinoma but not intrahepatic cholangiocarcinoma, the gene promotes extrahepatic cholangiocarcinoma metastasis by facilitating the epithelial-mesenchymal transition via the PLA2G4A/PGE2/STAT3 pathway [32]. Here, STAT3 is linked to intrahepatic cholangiocarcinoma.