Moreover, TNFAIP8 variant 2 has been identified as a p53-regulated gene product that exerts tumor-promoting effects through reciprocal regulatory interactions with p53, and depletion of TNFAIP8 variant 2 in MCF-7 cells was found to induce G1 or G2/M arrest [26]. Here, TNFAIP8 is linked to neoplasm.