Pathological staining analysis of the lymph node samples using HE staining and TNFAIP8 IHC staining also revealed that suppression of lncRNA H19 reduced significantly vacuole and necrosis lesions in lymph node tissues induced by tumor cells, as well as the expression level of TNFAIP8 protein (Fig. 6g). This evidence concerns the gene TNFAIP8 and neoplasm.