Importantly, our lncRNA H19 and TNFAIP8-silencing studies in steady-state BT-459 and MDA-MB-231 cells promoted progression and metastasis of breast cancer cells, and we demonstrated that enhanced lncRNA H19 expression abrogated the repressive effect of p53 on TNFAIP8 through competitively binding to p53, and this in turn induced EMT and metastasis of breast cancer cells. The gene discussed is TNFAIP8; the disease is breast cancer.