As previously mentioned that ACE-2 level increased in SARS-COV-2 patients to facilitate viral entry to host cells, Wan et al. (2020) added that the expression of ACE2 is also increased in patients with hypertension and diabetes due to treatment with ACE-2 increasing drug that are at high risk of COVID-19 and therefore should be treated with ACE inhibitors or angiotensin II type-I receptor blockers (ARBs). This evidence concerns the gene ACE2 and diabetes mellitus.