The association between four SNPs on chromosome 9p21, CAD, and MI has been replicated several times in multiple populations97–100 In patients with MI with ST-segment elevation Szpakowicz et al. revealed association between the rs12526453 of the phosphatase and actin regulator 1 (PHACTR1) gene and 5-year mortality101. Here, PHACTR1 is linked to coronary artery disorder.