Although illustrated for the AngII-infused ApoE−/− mouse model, this approach can also be used to study myriad mouse models of aneurysms and dissections that have previously been examined via standard biaxial testing (e.g., type II transforming growth factor receptor disruption63,64 and smooth muscle myosin heavy chain mutation65 to name a few). This evidence concerns the gene APOE and aneurysm.