For instance, Vétizou et al. demonstrated that an antibiotic cocktail consisting ampicillin, colistin, and streptomycin, or imipenem alone, abolished the cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) blockade and restored tumor progression in sarcoma, melanoma and CRC mouse models [91]. This evidence concerns the gene CTLA4 and sarcoma.