NFKB1 and neoplasm: Downstream interruption of KRAS-NF-κB signaling (i.e., inhibition of TBK1 with TBK1 shRNA; Fig. 2B-E) largely overcame integrin β3-mediated stemness (i.e., less tumor sphere formation in FGβ3 cells with TBK1 knockdown; Fig. 2D).