CASP3 and neoplasm: Immunohistochemistry for Cleaved Caspase-3 (an apoptosis marker) and Ki67 (a proliferation marker) on the tumor sections showed that the combination treatments significantly increased the Cleaved Caspase-3 positive cells (p < 0.001) (Fig. 7d, e) and decreased Ki67 positive cells (p < 0.01) (Supplementary Fig. 11).