Consistent with the partial protection of the Bax−/−Bak1−/−p53−/− T lymphoma cells afforded by additionally mutating Bim, in the Bax−/−Bak1−/−Bim−/−p53−/− T lymphoma cells release of Cytc into the cytosol was reduced, but not eliminated (Fig. 5d and Supplementary Fig. S2c). This evidence concerns the gene BAX and lymphoma.