PTK2 and colorectal carcinoma: Western blot results are shown in Fig. 7c; the expression of phosphorylated FAK (Tyr397, Tyr407, and 575/577), Src (Tyr416), and paxillin (Tyr) was decreased in FOXC2-AS1-knockdown cells, while enhancing FOXC2 rescued its expression, which implied that FOXC2-AS1/FOXC2 contributes to CRC metastasis by promoting FA formation via FAK signaling.