The ME7 model of delirium during dementia has, until now, been an exemplar for an inflammatory hypersensitivity (Murray et al., 2012), but these data show that these mice are also more vulnerable to “bioenergetic stressors.” Despite equivalent reductions in blood and CSF glucose, NBH animals are resilient to hypoglycemia-induced cognitive impairment but ME7 animals are vulnerable, whether induced by LPS or by insulin. Here, INS is linked to delirium.