IL1B and Hypoglycemia: To test whether IL-1β is necessary for LPS-induced hypoglycemia, we administered LPS (250 μg/kg, i.p.)and IL-1β (25 μg/kg, i.p.)to IL-1 receptor-1 knock-out (IL-1R1−/−) mice and c57BL/6J wild-type (WT) controls.