One possibility is that acute sickness impinges on cerebral metabolism through systemic metabolic changes; cerebral glucose uptake is reduced in a rat model of LPS-induced sepsis (Semmler et al., 2008), carbohydrate metabolism is decreased post-LPS (Irahara et al., 2018), and IL-1 has been demonstrated to induce hypoglycemia (Del Rey et al., 2006). The gene discussed is IL1B; the disease is Hypoglycemia.