PKD2 and autosomal dominant polycystic kidney disease: To test the model as a potential assay for studying cystogenesis as caused by ADPKD, kidney cells from an inducible genetic mouse model of Pkd2 inactivation (Pkd2fl/fl Pax8rtTA TetOCre +mTmG) were employed (cells from a Pkd1fl/flPax8rtTA TetOCre +mTmG mouse models also work; Fig. S1).