We explored alterations in tensin-1 protein abundance in human kidney cysts from ADPKD patients and found an almost complete depletion of the tensin-1 protein in the cystic tissue as compared to levels in normal human kidney tissue (Fig. 6D; Fig. S4;n=4 control samples and n=5 ADPKD cysts). This evidence concerns the gene TNS1 and autosomal dominant polycystic kidney disease.