The A152T mutation in tau greatly increases the risk of developing frontotemporal dementia in humans (34), and expression of this mutant tau in the nervous system of zebrafish larvae causes neurodegeneration, an accumulation of hyperphosphorylated tau, as occurs in human tauopathies, and impairment of proteasomal peptidase activity in the lysates (35) (Fig. 5A). This evidence concerns the gene MAPT and frontotemporal dementia.