HTT and Huntington disease: We also evaluated mutant huntingtin (mhtt) aggregates in the striatum, cerebral cortex and hippocampus of mutant HdhQ7/Q111 mice after saline or thioperamide treatment, as another pathological hallmark of HD (Arrasate and Finkbeiner, 2012; Giralt et al., 2012; Hoffner et al., 2007).