In fact, dopamine-depleting drugs such as tetrabenazine or dopamine-stabilizers as pridopidine showed neuroprotective effects in HD mice (Wang et al., 2010), and improve motor coordination abnormalities in HD patients (Huntington Study Group, 2006; de Yebenes et al., 2011), while specific D1R inhibition rescues electrophysiological changes in excitatory and inhibitory synaptic transmission in full-length HD mouse models (André et al., 2011b). This evidence concerns the gene DRD1 and Huntington disease.