While the non-significant decrease in G2-arrest observed upon siRNA-mediated knockdown of P70S6K may have been limited by potential heterogeneity in the level of knockdown achieved, the increase in cell death further suggests that dactolisib mediated inhibition of P70S6K is responsible for the sensitisation of lung adenocarcinoma cells to cisplatin treatment. Here, RPS6KB1 is linked to lung adenocarcinoma.