TP53 and lung adenocarcinoma: To investigate potential mechanisms of platinum resistance using a model consistent with the physiological pharmacokinetics of platinum therapy (Figure 1A), we applied this cisplatin pulse model to a panel of six lung adenocarcinoma cell lines with distinct TP53 mutation backgrounds (two wildtype lines, two mutant TP53 lines and two TP53 null) and measured the apoptotic response at 72 hr (Figure 1B).