However, as the specific knockdown of P70S6K with siRNA recapitulated the effects of dactolisib on p63, p21, γH2A.X, cleaved caspase 3 and apoptosis, it is likely that the elevated expression and activity of P70S6K in resistant lung adenocarcinoma cells is the functional target of dactolisib and a causal effector of platinum resistance in these cells. This evidence concerns the gene CASP3 and lung adenocarcinoma.